Kinases are dynamic proteins that can adopt several distinct conformational states.

Thats why we built KinaMetrix.

A webserver to investigate kinase conformations and inhibitor space.

On KinaMetrix.com you can:



Other sites you should visit to study kinases!

KLIFS                      KinaseSARfari                      KinMap


For any questions please head over to our FAQ

Schlessinger Lab                                                     Made with ❤ using Shiny                          

Database of Kinase Conformation Predictions From Kinformation

Database of Geometric Descriptors Describing Kinase Conformations

Database of Kinase Bound Ligands


3D scatterplot of kinase structure predictions using Kinformation

Annotate Kinase Conformation using Kinformation

Enrichment of Substructures per Kinase Conformation

The red line indicates enriched substructures below a p-value threshold of .05
Click on a point to visualize a substructure of interest as well as get links to the parent ligand and interaction maps seen in the structure (scroll down)
Search for fragments by SMILES string

Models of Kinases in Unseen Conformations


These Models are available for academic and educational use under a Academic Public License and is intended for non-commercial use.

For a commercial license please contact the Schlessinger laboratory.

To download models, select a row from the table below and click the 'Download selected models' button below

Download selected models

AlphaFold2 Models of Kinases


These Models are available for academic and educational use under a Academic Public License and is intended for non-commercial use.

For a commercial license please contact the Schlessinger laboratory.

  • These models were generated by AlphaFold2 to explore the conformational space of kinases.
  • The download object contains models generated using different multiple sequence alignment (MSA) depths, where lower MSA depths are more likely to explore novel conformational space.
  • Many of these models are of kinases in novel conformational states in which they have not yet been experimentally observed.

  • The preprint version of our paper on this study is available here: https://www.biorxiv.org/content/10.1101/2023.08.31.555779v2

To download models, click the button below. Note: download may take some time to begin, do not close page

Download models

How to cite us:

There are currently three articles that KinaMetrix is a part of, please cite all three if possible.
If you utilized this website by accessing the database, using Kinformation, or viewing our fragment database please refer to our following papers:
If you used any of the homology models of kinases in missing inactive conformations please cite our KinaMetrix article as well as the following:

How to contact us:

If you have any issues with the webserver in general, running Kinformation, accesing the fragment library, find any bugs, or have an idea for a helpful feature, please contact:
  • rayees(dot)rahman@icahn(dot)mssm(dot)edu
    Rayees is the principal server developer and maintainer. He also trained Kinformation and built the fragment libaries and network.
    For any questions about the kinase homology models, the geometric descriptors used to train Kinformation or about DFGModel, please contact:
    • peter(dot)ung@mssm(dot)edu
      Dr. Ung develped the algorithm to derive the geometric descriptors describing the DFG and αC-Helix motifs in kinases.
      He also created DFGModel and generated all the homology models available on this webserver.

      For general inquires please contact:
      • avner(dot)schlessinger@mssm(dot)edu
        Dr. Schlessinger is the principal investigator of this project.

      Our funding sources:

      This server is funded by:
      • National Institute of General Medical Sciences Integrated Pharmacological Sciences Training Program (T32GM062754) [Rayees Rahman]

      Software, databases and packages we use:



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