Enrichment of Substructures per Kinase Conformation
The red line indicates enriched substructures below a p-value threshold of .05
Click on a point to visualize a substructure of interest as well as get links to the parent ligand and interaction maps seen in the structure (scroll down)
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Models of Kinases in Unseen Conformations
These Models are available for academic and educational use under a Academic Public License and is intended for non-commercial use.
For a commercial license please contact the Schlessinger laboratory.
To download models, select a row from the table below and click the 'Download selected models' button below
If you have any issues with the webserver in general, running Kinformation, accesing the fragment library, find any bugs, or have an idea for a helpful feature, please contact:
rayees(dot)rahman@icahn(dot)mssm(dot)edu Rayees is the principal server developer and maintainer. He also trained Kinformation and built the fragment libaries and network.
For any questions about the kinase homology models, the geometric descriptors used to train Kinformation or about DFGModel, please contact:
peter(dot)ung@mssm(dot)edu Dr. Ung develped the algorithm to derive the geometric descriptors describing the DFG and αC-Helix motifs in kinases. He also created DFGModel and generated all the homology models available on this webserver.
For general inquires please contact:
avner(dot)schlessinger@mssm(dot)edu Dr. Schlessinger is the principal investigator of this project.
Our funding sources:
This server is funded by:
National Institute of General Medical Sciences Integrated Pharmacological Sciences Training Program (T32GM062754) [Rayees Rahman]